Article
The RpoB H₄₈₁Y rifampicin resistance mutation and an active stringent response reduce virulence and increase resistance to innate immune responses in Staphylococcus aureus.
The Journal of infectious diseases - 15 Mar 2013
Gao Wei, Cameron David R, Davies John K, Kostoulias Xenia, Stepnell Justin, Tuck Kellie L, Yeaman Michael R, Peleg Anton Y, Stinear Timothy P, Howden Benjamin P
Abstract excerpt
The occurrence of mutations in methicillin-resistant Staphylococcus aureus (MRSA) during persistent infection leads to antimicrobial resistance but may also impact host-pathogen interactions. Here, we investigate the host-pathogen consequences of 2 mutations arising in clinical MRSA during persistent infection: RpoB H₄₈₁Y, which is linked to rifampicin resistance, and RelA F₁₂₈Y, which is associated with an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.