Polymorphisms in the Bordetella pertussis virulence factor SphB1 and altered antigen expression of clinical isolates before and after acellular pertussis vaccination in Finland.

Abstract excerpt

BACKGROUND: Bordetella pertussis has adapted significantly following the transition from whole-cell vaccines (WCV) to acellular vaccines (ACV). While changes in vaccine antigens are well-documented, the evolution of processing factors like sphB1, a protease essential for the maturation of filamentous hemagglutinin (FHA) and adenylate cyclase toxin (ACT), remains unexplored. This study was aimed to characterize...

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