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Article

Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving.

The Journal of infectious diseases - 15 Jul 2015

Sealey Katie L, Harris Simon R, Fry Norman K, Hurst Laurence D, Gorringe Andrew R, Parkhill Julian, Preston Andrew

Abstract excerpt

A major outbreak of whooping cough, or pertussis, occurred in 2012 in the United Kingdom (UK), with nearly 10 000 laboratory-confirmed cases and 14 infant deaths attributed to pertussis. A worldwide resurgence of pertussis has been linked to switch to the use of acellular pertussis vaccines and the evolution of Bordetella pertussis away from vaccine-mediated immunity. We have conducted genomic analyses of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25489002
DOI: 10.1093/infdis/jiu665

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