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Article

Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis: A Phenome-Wide Association Study and Inverse Variance-Weighted Meta-Analysis.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Sept 2020

Kawai Vivian K, Shi Mingjian, Feng Qiping, Chung Cecilia P, Liu Ge, Cox Nancy J, Jarvik Gail P, Lee Ming T M, Hebbring Scott J, Harley John B, Kaufman Kenneth M, Namjou Bahram, Larson Eric, Gordon Adam S, Roden Dan M, Stein C Michael, Mosley Jonathan D

Abstract excerpt

OBJECTIVE: This study was undertaken to investigate the hypothesis that a genetic predisposition toward rheumatoid arthritis (RA) increases the risk of 10 cardiometabolic and autoimmune disorders previously associated with RA in epidemiologic studies, and to define new genetic pleiotropy present in RA. METHODS: Two approaches were used to test our hypothesis. First, we constructed a weighted genetic risk score...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32307929
DOI: 10.1002/art.41291
PMCID: PMC7572512

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