Colorectal cancer-associated PCBP1 mutations disrupt protein stability in a dominant-negative manner.

Abstract excerpt

Mutations in RNA-binding proteins are increasingly identified in cancers through tumor sequencing and are correlated with disease progression, therapy response, and overall patient outcomes, underscoring the need to study them. Here, we focus on the RNA-binding protein Poly-C binding protein 1 (PCBP1), which binds target RNAs through K-homology (KH) domains to regulate RNA fate. PCBP1 is a tumor suppressor gene...

Topics

• RNA-Binding Proteins
• Humans
• Colorectal Neoplasms
• Protein Stability
• Heterogeneous-Nuclear Ribonucleoproteins