The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma.

doi:10.1002/gcc.22268

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Article

The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma.

Genes, chromosomes & cancer - 1 Sept 2015

Wagener Rabea, Aukema Sietse M, Schlesner Matthias, Haake Andrea, Burkhardt Birgit, Claviez Alexander, Drexler Hans G, Hummel Michael, Kreuz Markus, Loeffler Markus, Rosolowski Maciej, López Cristina, Möller Peter, Richter Julia, Rohde Marius, Betts Matthew J, Russell Robert B, Bernhart Stephan H, Hoffmann Steve, Rosenstiel Philip, Schilhabel Markus, Szczepanowski Monika, Trümper Lorenz, Klapper Wolfram, Siebert Reiner

Abstract excerpt

The genetic hallmark of Burkitt lymphoma is the translocation t(8;14)(q24;q32), or one of its light chain variants, resulting in IG-MYC juxtaposition. However, these translocations alone are insufficient to drive lymphomagenesis, which requires additional genetic changes for malignant transformation. Recent studies of Burkitt lymphoma using next generation sequencing approaches have identified various recurrently...

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Identifiers

PMID: 26173642
DOI: 10.1002/gcc.22268

Genes

PCBP1
CCND3
MYC
TCF3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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