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Article

Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer

20 Aug 2019

Abstract excerpt

BACKGROUND: Microsatellite unstable colorectal cancers (MSI+ CRCs) expressing PD-L1, respond to anti-PD-1 or anti-PD-L1 checkpoint blockade, whereas microsatellite-stable tumors do not respond the same. Our aim was to examine how the immune landscape relates to different aspects of the CRC's biology, including neoepitope burden. METHODS: We used TCGA data to stratify patients based on a cytolytic T-cell activity...

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PMID: 31429779
DOI: 10.1186/s13046-019-1372-z

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