Imputation in the Wild: Genome-Wide Robustness and Fine-Scale Limitations of Low-Coverage Genomes in Endangered Species.

Abstract excerpt

Low-coverage whole-genome sequencing (lcWGS) combined with genotype imputation is increasingly being used to generate large genomic datasets at reduced cost, offering a promising alternative for conservation genomics. Here, we use the Iberian lynx (Lynx pardinus), a species with extremely low genetic diversity, genetically differentiated populations, and recent admixture, as a case study to evaluate the...

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