Integrative analysis of FAERS, network toxicology, and Mendelian randomization identifies potential targets in paclitaxel-associated systemic sclerosis.

Abstract excerpt

Systemic sclerosis (SSc) is a rare and complex autoimmune disease characterized by fibrosis of the skin and internal organs as well as vascular abnormalities. Studies have suggested that paclitaxel may induce adverse reactions resembling systemic sclerosis; however, the underlying mechanisms remain not fully understood. We retrieved reports of paclitaxel-associated SSc from the FDA Adverse Event Reporting System...

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