Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mis-localized nucleoporin POM121C potently inhibits nuclear entry of HIV-1 but leads to the outgrowth of viral escape mutants.

Journal of virology - 18 Aug 2026

Saito Hideki, Miyagi Eri, Kao Sandra, Dai Annie, Rashid Mohammad M, Yang Darian T, Chakraborty Rajasree, Dash Chandravanu, Gronenborn Angela M, Diaz-Griffero Felipe, Strebel Klaus

Abstract excerpt

Nuclear entry of HIV-1 involves specific interactions between the viral capsid and components of the nuclear pore complex. FG-repeat sequences present in many nucleoporins play important roles in HIV-1 nuclear entry. We previously reported that overexpression of the FG repeat-containing C-terminal fragment of the nucleoporin POM121C (residues 614-987), termed POM987, inhibits HIV-1 infection. However, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Capsid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Capsid Proteins

Share to HEK293 Cells

Share to HeLa Cells

Share to Membrane Glycoproteins

Share to Nuclear Pore Complex Proteins

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 42489472
DOI: 10.1128/jvi.00312-26
PMCID: PMC13483366

Genes

POM121C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mis-localized nucleoporin POM121C potently inhibits nuclear entry of HIV-1 but leads to the outgrowth of viral escape mutants.PMID 42489472Read ↗

A dominant-negative form of POM121 binds chromatin and disrupts the two separate modes of nuclear pore assembly.Semantic proximity Read ↗

The HIV-1 capsid core is an opportunistic nuclear import receptorSemantic proximity Read ↗

Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells.Semantic proximity Read ↗

The nuclear pore protein NUP98 impedes LTR-driven basal gene expression of HIV-1, viral propagation, and infectivitySemantic proximity Read ↗

HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear EntrySemantic proximity Read ↗

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA IntegrationSemantic proximity Read ↗

Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid.Semantic proximity Read ↗

The Requirement for Nucleoporin NUP153 during Human Immunodeficiency Virus Type 1 Infection Is Determined by the Viral CapsidSemantic proximity Read ↗

Lenacapavir binding to immature Gag triggers the emergence of giant HIV-1 virionsSemantic proximity Read ↗

Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replicationSemantic proximity Read ↗

NLS-mediated NPC functions of the nucleoporin Pom121.Semantic proximity Read ↗

The Role of Capsid in HIV-1 Nuclear EntrySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.