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Article

NLS-mediated NPC functions of the nucleoporin Pom121.

FEBS letters - 4 Aug 2010

Yavuz Sevil, Santarella-Mellwig Rachel, Koch Birgit, Jaedicke Andreas, Mattaj Iain W, Antonin Wolfram

Abstract excerpt

RanGTP mediates nuclear import and mitotic spindle assembly by dissociating import receptors from nuclear localization signal (NLS) bearing proteins. We investigated the interplay between import receptors and the transmembrane nucleoporin Pom121. We found that Pom121 interacts with importin alpha/beta and a group of nucleoporins in an NLS-dependent manner. In vivo, replacement of Pom121 with an NLS mutant version...

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Identifiers

PMID: 20624389
DOI: 10.1016/j.febslet.2010.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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