Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells.

Journal of virology - 1 Oct 2018

Buffone Cindy, Martinez-Lopez Alicia, Fricke Thomas, Opp Silvana, Severgnini Marco, Cifola Ingrid, Petiti Luca, Frabetti Stella, Skorupka Katarzyna, Zadrozny Kaneil K, Ganser-Pornillos Barbie K, Pornillos Owen, Di Nunzio Francesca, Diaz-Griffero Felipe

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) displays the unique ability to infect nondividing cells. The capsid of HIV-1 is the viral determinant for viral nuclear import. To understand the cellular factors involved in the ability of HIV-1 to infect nondividing cells, we sought to find capsid mutations that allow the virus to infect dividing but not nondividing cells. Because the interaction of capsid with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Capsid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Division

Share to Gene Knockdown Techniques

Share to mRNA Cleavage and Polyadenylation Factors

Share to Nuclear Pore

Share to Nuclear Pore Complex Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29997211
DOI: 10.1128/JVI.00648-18
PMCID: PMC6146805

Genes

CPSF6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells.PMID 29997211Read ↗

Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity.Semantic proximity Read ↗

Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replicationSemantic proximity Read ↗

The Requirement for Nucleoporin NUP153 during Human Immunodeficiency Virus Type 1 Infection Is Determined by the Viral CapsidSemantic proximity Read ↗

The HIV-1 capsid core is an opportunistic nuclear import receptorSemantic proximity Read ↗

Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.Semantic proximity Read ↗

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA IntegrationSemantic proximity Read ↗

The Role of Capsid in HIV-1 Nuclear EntrySemantic proximity Read ↗

Mis-localized nucleoporin POM121C potently inhibits nuclear entry of HIV-1 but leads to the outgrowth of viral escape mutants.Semantic proximity Read ↗

HIV-1 uncoats in the nucleus near sites of integrationSemantic proximity Read ↗

HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear EntrySemantic proximity Read ↗

Nuclear import of APOBEC3F-labeled HIV-1 preintegration complexes.Semantic proximity Read ↗

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA IntegrationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.