Article
Molecular tumor board: H3K27M diffuse midline glioma diagnosed during pregnancy by cerebrospinal fluid next-generation sequencing.
The oncologist - 9 Sept 2026
Sherman Jason B, Harbaugh Thaddeus D, Sisto Alexander, Sherwani Zohaib, Jan Imraan, Norrell Jacqueline, Sherman Jonathan H, Udhane Vindhya, Schilter Kala F, Nie Qian, Reddi Honey V, Vojnic Morana
Abstract excerpt
BACKGROUND: Diffuse midline glioma (DMG) with the H3K27M mutation is an aggressive WHO grade 4 central nervous system tumor characterized by diffuse infiltration of midline structures and a poor prognosis. Molecular characterization is essential for diagnosis and treatment planning; however, obtaining tissue can be infeasible, particularly in anatomically inaccessible locations or medically complex situations,...
Read the complete abstract on PubMedTopics
- Humans
- Female
- Pregnancy
- Adult
- Glioma
- High-Throughput Nucleotide Sequencing