Article
Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma.
Neuro-oncology - 5 Jan 2023
Messinger Dana, Harris Micah K, Cummings Jessica R, Thomas Chase, Yang Tao, Sweha Stefan R, Woo Rinette, Siddaway Robert, Burkert Martin, Stallard Stefanie, Qin Tingting, Mullan Brendan, Siada Ruby, Ravindran Ramya, Niculcea Michael, Dowling Abigail R, Bradin Joshua, Ginn Kevin F, Gener Melissa A H, Dorris Kathleen, Vitanza Nicholas A, Schmidt Susanne V, Spitzer Jasper, Li Jiang, Filbin Mariella G, Cao Xuhong, Castro Maria G, Lowenstein Pedro R, Mody Rajen, Chinnaiyan Arul, Desprez Pierre-Yves, McAllister Sean, Dun Matthew D, Hawkins Cynthia, Waszak Sebastian M, Venneti Sriram, Koschmann Carl, Yadav Viveka Nand
Abstract excerpt
BACKGROUND: Diffuse midline gliomas (DMG) are highly invasive brain tumors with rare survival beyond two years past diagnosis and limited understanding of the mechanism behind tumor invasion. Previous reports demonstrate upregulation of the protein ID1 with H3K27M and ACVR1 mutations in DMG, but this has not been confirmed in human tumors or therapeutically targeted. METHODS: Whole exome, RNA, and ChIP-sequencing...
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