Article
A systematic analysis highlights multiple long non-coding RNAs associated with cardiometabolic disorders.
Journal of human genetics - 1 Apr 2018
Ghanbari Mohsen, Peters Marjolein J, de Vries Paul S, Boer Cindy G, van Rooij Jeroen G J, Lee Yu-Chi, Kumar Vinod, Uitterlinden André G, Ikram M Arfan, Wijmenga Cisca, Ordovas Jose M, Smith Caren E, van Meurs Joyce B J, Erkeland Stefan J, Franco Oscar H, Dehghan Abbas
Abstract excerpt
Genome-wide association studies (GWAS) have identified many susceptibility loci for cardiometabolic disorders. Most of the associated variants reside in non-coding regions of the genome including long non-coding RNAs (lncRNAs), which are thought to play critical roles in diverse biological processes. Here, we leveraged data from the available GWAS meta-analyses on lipid and obesity-related traits, blood pressure,...
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