Article
A targeted multi-omics approach reveals paraoxonase-1 as a determinant of obesity-associated fatty liver disease.
Clinical epigenetics - 13 Aug 2021
Diels Sara, Cuypers Bart, Tvarijonaviciute Asta, Derudas Bruno, Van Dijck Evelien, Verrijken An, Van Gaal Luc F, Laukens Kris, Lefebvre Philippe, Ceron Jose J, Francque Sven, Vanden Berghe Wim, Van Hul Wim
Abstract excerpt
BACKGROUND: The multifactorial nature of non-alcoholic fatty liver disease cannot be explained solely by genetic factors. Recent evidence revealed that DNA methylation changes take place at proximal promoters within susceptibility genes. This emphasizes the need for integrating multiple data types to provide a better understanding of the disease's pathogenesis. One such candidate gene is paraoxonase-1 (PON1)....
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