Article
Identification of divergent PTPN11 mutations in canine histiocytic sarcomas reveals evidence of an independent clonal origin.
PloS one - 1 Jan 2026
Mottier Stéphanie, Houel Armel, Bouchard Solveig, Bianchi Charline, Le Nezet Louis, Guyon Richard, Dreano Stéphane, Derrien Thomas, Abadie Jerôme, André Catherine, Hédan Benoît
Abstract excerpt
BACKGROUND: Histiocytic sarcoma (HS) is a rare but highly aggressive neoplasm in humans, with limited knowledge on indicators markers and no standardized treatment. Dogs naturally develop HS, offering a powerful comparative model. Activating mutations in PTPN11, affecting two recurrent hotspots (E76 and G503), are the most frequent drivers of canine HS and are strongly associated with the disseminated form (DHS)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.