Article

Interest of circulating tumor DNA as a biomarker for canine cancers: illustration in histiocytic sarcoma, oral malignant melanoma and multicentric lymphoma

2020-07-11

Abstract excerpt

Circulating tumor DNA (ctDNA) has become an attractive biomarker in human oncology and may be informative in cancer-affected dogs. By performing ddPCR or PARR methods, we detected tumor-specific point mutations, copy number alterations and chromosomal rearrangements in the plasma of cancer-affected dogs. It allowed the detection of ctDNA in 2/8 (25%) oral malignant melanoma cases, 12/13 (92.3%) lymphoma cases and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b0321dd3-71cc-5e2b-9e7d-e705212739c8
DOI: 10.1101/2020.07.10.189118

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interest of circulating tumor DNA as a biomarker for canine cancers: illustration in histiocytic sarcoma, oral malignant melanoma and multicentric lymphomaDOI 10.1101/2020.07.10.189118Read

Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma.Semantic proximity Read

Individualized circulating tumor DNA monitoring in two dogs with malignant melanoma.Semantic proximity Read

Plasma cell-free DNA in canine lymphoma patients as a novel material for genotyping.Semantic proximity Read

Whole Genome 3D Blood Biopsy Profiling of Canine Cancers: Development and Validation of EpiSwitch Multi-Choice Array-Based Diagnostic TestSemantic proximity Read

Identification of divergent PTPN11 mutations in canine histiocytic sarcomas reveals evidence of an independent clonal origin.Semantic proximity Read

Feasibility of circulating tumor DNA analysis in dogs with naturally occurring malignant and benign splenic lesions.Semantic proximity Read

Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in DogsSemantic proximity Read

Immune pathways and TP53 missense mutations are associated with longer survival in canine osteosarcomaSemantic proximity Read

Clinical Use of Molecular Biomarkers in Canine and Feline Oncology: Current and FutureSemantic proximity Read

PTPN11 mutations in canine and human disseminated histiocytic sarcoma.Semantic proximity Read

The K9 lymphoma assay allows a genetic subgrouping of canine lymphomas with improved risk classificationSemantic proximity Read

Analyses of canine cancer mutations and treatment outcomes using real-world clinico-genomics data of 2119 dogsSemantic proximity Read