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Article

Protective Role of The SIGLEC14 Null Allele Against Type 2 Diabetes Mellitus: Evidence From an Egyptian Case-Control Study.

Molecular biology reports - 20 Jul 2026

Gabr Yasmine E, Arafa Lamiaa F, Morsi Heba K, Hammad Maha O

Abstract excerpt

BACKGROUND: Chronic inflammation plays a central role in the pathogenesis of type 2 diabetes mellitus (T2DM), with emerging evidence highlighting the regulatory role of sialic acid-binding immunoglobulin-like lectins (SIGLECs). The SIGLEC-14 null polymorphism, resulting in reduced pro-inflammatory signalling, may influence susceptibility to T2DM. This study aimed to investigate the association between the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42474780
DOI: 10.1007/s11033-026-12323-7

Genes

SIGLEC14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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