Article
The association between the HLA-G 14-bp insertion/deletion polymorphism and type 1 diabetes.
Genes and immunity - 1 Jan 2000
Silva H P V, Ururahy M A G, Souza K S C, Loureiro M B, Oliveira Y M C, Oliveira G H M, Luchessi A D, Carvalho K T C, Freitas J C O C, Donadi E A, Hirata R D C, Almeida M G, Arrais R F, Hirata M H, Rezende A A
Abstract excerpt
Type 1 diabetes (T1D) is a multifactorial disease that has a strong genetic component. The HLA-G is a nonclassical HLA class I locus that is associated with immunomodulatory functions, including downregulation of innate and adaptive immune responses and induction of immune tolerance. However, there is currently limited information about the involvement of HLA-G in T1D susceptibility. This case-control study aims...
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