The association between CD14 (C-159T) single-nucleotide polymorphism and Behcet's syndrome and its clinical manifestations in Egyptian patients, an observational case-control genetic association study.

Abstract excerpt

BACKGROUND: Cluster of differentiation 14 (CD14) molecules are immune cell surface molecules that bind and display lipopolysaccharides (LPSs) of gram-negative bacteria to Toll-like receptor 4 (TLR4), facilitating LPS-induced immune cell activation. The CD14 promoter polymorphism C-159T is positively correlated with CD14, and homozygous carriers of the T allele have a significant increase in soluble and...

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