Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression and regulatory characteristics of peripheral blood immune cells in primary Sjögren’s syndrome patients using single-cell transcriptomic

4 Nov 2022

Abstract excerpt

Immune cell subgroups in peripheral blood mononuclear cells (PBMCs) in primary Sjogren's syndrome (pSS) are thought to regulate immune responses, but the nature and functions of these subgroups remain unclear. Here we performed single-cell RNA sequencing (scRNA-seq) of about 68,500 PBMCs from three patients with pSS and three healthy controls (HCs). We found that CD14 + monocytes from pSS patients expressed high...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Salivary Gland Disorders and Functions
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36425764
DOI: 10.1016/j.isci.2022.105509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression and regulatory characteristics of peripheral blood immune cells in primary Sjögren’s syndrome patients using single-cell transcriptomicPMID 36425764Read ↗

Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s SyndromeSemantic proximity Read ↗

Analysis of Gene Expression and TCR/B Cell Receptor Profiling of Immune Cells in Primary Sjögren’s Syndrome by Single-Cell SequencingSemantic proximity Read ↗

Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren's syndromeSemantic proximity Read ↗

The Transcriptomic Profile of Monocytes from Patients With Sjögren’s Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating MediatorsSemantic proximity Read ↗

Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren’s syndromeSemantic proximity Read ↗

Single-Cell RNA-Sequencing Integration Analysis Revealed Immune Cell Heterogeneity in Five Human Autoimmune DiseasesSemantic proximity Read ↗

LncRNA and mRNA expression profile of peripheral blood mononuclear cells in primary Sjögren’s syndrome patientsSemantic proximity Read ↗

KLRB1 defines an activated phenotype of CD4+ T cells and shows significant upregulation in patients with primary Sjögren's syndrome.Semantic proximity Read ↗

LncRNA and mRNA expression profile of peripheral blood mononuclear cells in primary Sjögren’s syndrome patientsSemantic proximity Read ↗

Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren’s diseaseSemantic proximity Read ↗

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndromeSemantic proximity Read ↗

Transcriptome Sequencing Reveals Potential Roles of ICOS in Primary Sjögren’s SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.