Article
Intramuscular patient-derived xenografts achieve high engraftment rates in gastric cancer: implications for pharmacodynamic testing and genomic biomarker discovery.
Annals of medicine - 1 Dec 2026
Li Bin, Wang Baogui, Song Hang, Zheng Hui, Wang Qian, Deng Jingyu, Wang Xiaona, Liu Ning, Pan Yuan, Zhan Hongjie, Ding Xuewei, Wang Xuejun, Zhang Rupeng, Zhu Yanping, Liang Han, Liu Yong
Abstract excerpt
BACKGROUND: Gastric cancer (GC) exhibits marked inter-patient heterogeneity, limiting empirical chemotherapy efficacy. Patient-derived xenograft (PDX) models preserve the molecular features of parental tumors and can serve as pharmacodynamic surrogates, but conventional subcutaneous PDX suffers from low engraftment rates. This study evaluated an optimized intramuscular PDX platform for individualized drug testing...
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