Article

Personalizing Breast Cancer Treatment with Patient-derived Xenografts (PDX): Analyzing PDXs Fidelity, Stability, and Intra-Tumoral Heterogeneity

2025-06-13

Abstract excerpt

<title>Abstract</title> <p>Breast cancer (BC) is a complex disease with varied histology and molecular behaviors. Patient-derived xenografts (PDXs) have been developed to study tumor progression and personalized treatment strategies. Here, we assessed the stability and fidelity of BC PDXs in maintaining key characteristics of their source biopsies across generations and various engraftment sites in mice. Using NS...

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Literature Corpus work: 987fec15-cdf6-5ca0-a9f3-02cc9ffe6337
DOI: 10.21203/rs.3.rs-6730867/v1

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