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Article

Pleiotropic gene mapping reveals shared immune regulatory hubs across 15 autoimmune diseases.

Human immunology - 1 Feb 2026

Jin Yi, Lu Hui-Min, Yu Xing-Hao

Abstract excerpt

BACKGROUND: Autoimmune diseases (AIDs) involve immune dysfunction with complex genetic underpinnings. This study examined genetic correlations and directional genetic associations across 15 AIDs to identify common immune pathways. METHODS: We retrieved GWAS summary statistics for 15 AIDs and analyzed genetic overlap using LDSC and Z-score correlations. Pleiotropy was assessed via MAGMA to assign SNPs to genes and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41406704
DOI: 10.1016/j.humimm.2025.111636

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NOTCH4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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