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Article

Craspase Protease Activation Is Sensitive to Oncogenic Single-Nucleotide RNA Mismatches.

ACS chemical biology - 21 Aug 2026

Feldmann Dani, van Beljouw Sam P B, Haagsma Anna C, Kalogeropoulos Konstantinos, Muralidharan Aswin, Brouns Stan J J

Abstract excerpt

The type III-E CRISPR-controlled protease Craspase is distinguished from other type III systems by its single-subunit RNA-guided protein complex and direct coupling of RNA recognition to protease activation without second messenger signaling, making it an attractive development platform for bioengineering and therapeutics. Here, we identify five positions within the CRISPR RNA (crRNA) of Craspase from Candidatus...

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Share to Base Pair Mismatch
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42454678
DOI: 10.1021/acschembio.6c00241
PMCID: PMC13505182

Genes

KRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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