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Cognitive reserve, genetic risk, and lifestyle in the incidence and progression of type 2 diabetes: A large community-based longitudinal study.

Diabetes, obesity & metabolism - 1 Oct 2025

Han Shaojie, Hu Xiaomei, Zhang Zenghui, Li Yan, Guo Chuxian, Li Panpan, Liu Zhaoyu, Guo Jun

Abstract excerpt

AIMS: While high cognitive reserve (CR) is associated with a reduced risk of dementia, its potential link to type 2 diabetes (T2D) has not been well established. This study aimed to investigate the relationship between CR and both the incidence and trajectory of T2D, and to assess whether these associations differ depending on genetic predisposition and lifestyle behaviours. MATERIALS AND METHODS: We included...

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PMID: 40677089
DOI: 10.1111/dom.16622

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