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Article

HLA-E-Directed Accumulation of KIR+NKG2C+ NK Cells upon HCMV Peptide Presentation In Vitro: Association with the Ex Vivo Phenotype.

International journal of molecular sciences - 7 Jul 2026

Alekseeva Nadezhda A, Ustiuzhanina Maria O, Streltsova Maria A, Vavilova Julia D, Sapozhnikov Alexander M, Kovalenko Elena I

Abstract excerpt

NK cells co-expressing NKG2C and inhibitory KIRs represent promising effector candidates when directed against HLA-E+ tumors. These cells may propagate in vitro upon HCMV peptide (LFL) presentation within HLA-E by interacting cells due to KIR+NKG2C+ cell expansion or via NKG2C or KIR de novo expression. This study aimed to clarify whether these accumulation mechanisms are connected to the healthy individual's ex...

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Share to Cytomegalovirus
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-E Antigens

Share to Killer Cells, Natural

Share to NK Cell Lectin-Like Receptor Subfamily C

Share to Receptors, KIR

Share to Receptors, KIR2DL2

Share to Receptors, KIR2DL3

Source

Open in PubMed Open full text

Identifiers

PMID: 42450353
DOI: 10.3390/ijms27136087
PMCID: PMC13362507

Genes

KIR2DL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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