Article
Distinctive phenotype for HLA-E- versus HLA-A2-restricted memory CD8 αβT cells in the course of HCMV infection discloses features shared with NKG2C+CD57+NK and δ2-γδT cell subsets.
Frontiers in immunology - 1 Jan 2022
Rousselière Amélie, Gérard Nathalie, Delbos Laurence, Guérif Pierrick, Giral Magali, Bressollette-Bodin Céline, Charreau Béatrice
Abstract excerpt
The human cytomegalovirus (HCMV) triggers both innate and adaptive immune responses, including protective CD8+ αβT cells (CD8T) that contributes to the control of the infection. In addition to CD8T restricted by classical HLA class Ia molecules, HCMV also triggers CD8T recognizing peptides from the HCMV UL40 leader peptide and restricted by HLA-E molecules (HLA-EUL40 CD8T). This study investigated the frequency,...
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