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Article

CMV drives clonal expansion of NKG2C + NK cells expressing self‐specific KIRs in chronic hepatitis patients

22 Nov 2011

Abstract excerpt

Natural killer (NK) cells are affected by infection with human cytomegalovirus (HCMV) manifested by increased expression of the HLA-E binding activating receptor NKG2C. We here show that HCMV seropositivity was associated with a profound expansion of NKG2C(+) CD56(dim) NK cells in patients with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. Multi-color flow cytometry revealed that the...

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PMID: 22105371
DOI: 10.1002/eji.201141826

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