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Article

Activation of the Endothelin System in Chronic Kidney Disease and Kidney Transplant Recipients-Implications for Disease Progression.

International journal of molecular sciences - 23 Jun 2026

Ściskalska Milena, Król-Kulikowska Magdalena, Grzybowska Julia, Tabaka Ewa, Pabian Wiktoria, Pisarek Dominika, Benc Krzysztof, Kuriata-Kordek Magdalena, Banasik Mirosław, Kepinska Marta

Abstract excerpt

The endothelin system is critical in chronic kidney disease (CKD) pathogenesis. However, the relative contribution of circulating endothelin-related biomarkers versus genetic variability remains unclear, particularly in diabetic nephropathy (DN) and after kidney transplantation (KTx). This study evaluated plasma concentrations of endothelin-1 (ET-1), endothelin A receptor (ETAR), and anti-ETAR antibodies...

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Source

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Identifiers

PMID: 42449925
DOI: 10.3390/ijms27135647
PMCID: PMC13360933

Genes

EDN1
EDNRA
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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