Genetic variant in the 5' untranslated region of endothelin1 (EDN1) gene in children with primary nephrotic syndrome.

doi:10.1002/jbt.22963

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Article

Genetic variant in the 5' untranslated region of endothelin1 (EDN1) gene in children with primary nephrotic syndrome.

Journal of biochemical and molecular toxicology - 1 Mar 2022

Yahia Sohier, Hammad Ayman, El-Gilany Abdel-Hady, El-Assmy Mohamed, El-Tanbouly Rasha, Elsaid Afaf M, Elmoursi Lamiaa Z, Elshazli Rami M, Shoaib Rasha Ms

Abstract excerpt

Endothelin-1 plays a crucial role in the pathophysiology of nephrotic syndrome (NS) in children. The primary purpose of this study is to evaluate the contribution of the EDN1 (3A/4A; rs1800997) variant to the risk of nephrotic syndrome. This study involves 200 participants (100 healthy controls, 50 steroid-sensitive nephrotic syndromes [SSNS] patients, and 50 steroid-resistant nephrotic syndromes [SRNS]...

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PMID: 34783119
DOI: 10.1002/jbt.22963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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