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Article

Large-scale quaternary structural transitions underlie gain of function of SPOP cancer mutations.

Molecular cell - 6 Aug 2026

Cuneo Matthew J, Güllülü Ömer, Ammar Mohamed-Raafet, Gui Xinrui, Churion Kelly, Turk Martin, O'Flynn Brian G, Sabri Nafiseh, Mittag Tanja

Abstract excerpt

Speckle-type POZ protein (SPOP), a substrate receptor for the Cullin-3-RING (CRL3) ubiquitin ligase, is mutated in different cancers. Both activating and inactivating mutations in SPOP drive oncogenesis, underscoring the need for precise regulation. Among substrate receptors, SPOP uniquely assembles into filaments that are multivalent for substrate binding. Conversely, many substrates contain multiple...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42442353
DOI: 10.1016/j.molcel.2026.06.030
PMCID: PMC13372211

Genes

SPOP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Large-scale quaternary structural transitions underlie gain of function of SPOP cancer mutations.PMID 42442353Read ↗

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Functional dissection of SPOP at the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesis.Semantic proximity Read ↗

SPOP in Cancer: Phenomena, Mechanisms and Its Role in Therapeutic ImplicationsSemantic proximity Read ↗

Functional dissection of <i>SPOP</i> on the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesisSemantic proximity Read ↗

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