Article

Functional dissection of <i>SPOP</i> on the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesis

2025-08-24

Abstract excerpt

Numerous proteins display pleiotropic functions in different clinical contexts. However, molecular mechanism underlying such effects is rarely understood. Speckle-type POZ protein ( SPOP ) is a typical example, exhibiting tumor-suppressing or -promoting effects in different tumor types in accordance with different amino acid changes; specifically, two distinct sets of variants in SPOP are commonly found in subse...

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Identifiers and source

Literature Corpus work: 967fb792-45e1-5160-915a-518c202a5562
DOI: 10.1101/2025.08.20.671394

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