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Article

Functional dissection of SPOP at the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2026

Park Seong Kyun, Lee Jeongha, Park Seon Ju, Kim Ye Na, Shin Gi Hyun, Dan Kisoon, Choi Hee-Jung, Han Dohyun, Hwang Byung Joon, Choi Murim

Abstract excerpt

Numerous proteins display pleiotropic functions in different clinical contexts. However, the molecular mechanism underlying such effects is rarely understood. Speckle-type POZ protein (SPOP) is a typical example, exhibiting tumor-suppressing or tumor-promoting effects in different tumor types in accordance with different amino acid changes; specifically, two distinct sets of variants in SPOP are commonly found in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42090249
DOI: 10.1073/pnas.2523210123
PMCID: PMC13167761

Genes

SPOP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Functional dissection of SPOP at the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesis.PMID 42090249Read ↗

Functional dissection of <i>SPOP</i> on the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesisSemantic proximity Read ↗

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Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation.Semantic proximity Read ↗

Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics.Semantic proximity Read ↗

SPOP Mutations Target STING1 Signaling in Prostate Cancer and Create Therapeutic Vulnerabilities to PARP Inhibitor-Induced Growth Suppression.Semantic proximity Read ↗

Deregulation of SPOP in Cancer.Semantic proximity Read ↗

Systematic Characterization of Cancer-Associated SPOP Mutants Reveals Novel and Reprogrammable Degradative Activities.Semantic proximity Read ↗

Speckle-type POZ protein mutations interrupt tumor suppressor function of speckle-type POZ protein in prostate cancer by affecting androgen receptor degradation.Semantic proximity Read ↗

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