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Article

Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines.

Immunology and cell biology - 1 Mar 2011

Ahmed Rafi, Akondy Rama S

Abstract excerpt

Live virus vaccines provide a unique opportunity to study human CD8(+) T-cell memory in the context of a controlled, primary acute viral infection. Yellow fever virus-17D and Dryvax are two such live-virus vaccines that are highly efficacious, used worldwide and provide long-term immunity against yellow fever and smallpox respectively. In this review, we describe the properties of virus-specific memory CD8(+) T...

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PMID: 21301482
DOI: 10.1038/icb.2010.155

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