Article

Influence of CYP2C19, CYP2D6 and CYP3A4 genetic variants on the biological effect of malaria treatment with primaquine in G6PD- deficient and G6PD-normal patients

2023-03-06

Abstract excerpt

<title>Abstract</title> <p>Background In the Amazon, <italic>Plasmodium vivax</italic> is the prevalent malaria parasite, and the standard treatment is chloroquine combined with primaquine. However, this regimen is limited because of the risk of acute hemolytic anemia (AHA) in glucose-6-phosphate dehydrogenase deficient individuals (G6PDd). CYP2D6 is a key enzyme that is involved in the metabolism of a large num...

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Literature Corpus work: 05d8bb58-87ad-597e-85a4-1635d37eede3
DOI: 10.21203/rs.3.rs-2640379/v1

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