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Article

Fusion-deficient insertion mutants of herpes simplex virus type 1 glycoprotein B adopt the trimeric postfusion conformation.

Journal of virology - 1 Feb 2010

Silverman Jessica L, Sharma Sapna, Cairns Tina M, Heldwein Ekaterina E

Abstract excerpt

Glycoprotein B (gB) enables the fusion of viral and cell membranes during entry of herpesviruses. However, gB alone is insufficient for membrane fusion; the gH/gL heterodimer is also required. The crystal structure of the herpes simplex virus type 1 (HSV-1) gB ectodomain, gB730, has demonstrated similarities between gB and other viral fusion proteins, leading to the hypothesis that gB is a fusogen, presumably...

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Identifiers

PMID: 19939928
DOI: 10.1128/JVI.01791-09
PMCID: PMC2812406

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