A Dictyostelium discoideum Cell-Based Biosensor Reveals Capsule-Associated Virulence Phenotypes in Hypervirulent Klebsiella pneumoniae.

Abstract excerpt

Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging threat due to its capacity to cause severe community-acquired infections and its increasing convergence with multidrug resistance. However, functional assessment of hvKp virulence still relies largely on mammalian infection models, which are costly, ethically constrained, and poorly suited for scalable early-stage screening. Here, we establish a...

Topics

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• Bacterial Capsules
• Biosensing Techniques
• Dictyostelium
• Klebsiella pneumoniae
• Phenotype