Article
Dictyostelium discoideum as a model host for meningococcal pathogenesis.
Medical science monitor : international medical journal of experimental and clinical research - 1 Jul 2008
Colucci Anna Maria Rosaria, Peracino Barbara, Tala Adelfia, Bozzaro Salvatore, Alifano Pietro, Bucci Cecilia
Abstract excerpt
BACKGROUND: The aim of the present study was to evaluate the possibility of studying meningococcal virulence in a new model organism, Dictyostelium discoideum, a haploid social soil amoeba that is an established host model for several human pathogens, leading to the discovery of novel virulence mechanisms. MATERIAL/METHODS: A number of virulent and hyper-virulent N. meningitidis strains, including isogenic...
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