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Article

Inorganic Polyphosphate Is Essential for Salmonella Typhimurium Virulence and Survival in Dictyostelium discoideum.

Frontiers in cellular and infection microbiology - 1 Jan 2018

Varas Macarena A, Riquelme-Barrios Sebastián, Valenzuela Camila, Marcoleta Andrés E, Berríos-Pastén Camilo, Santiviago Carlos A, Chávez Francisco P

Abstract excerpt

Inorganic polyphosphate (polyP) deficiency in enteric bacterial pathogens reduces their ability to invade and establish systemic infections in different hosts. For instance, inactivation of the polyP kinase gene (ppk) encoding the enzyme responsible for polyP biosynthesis reduces invasiveness and intracellular survival of Salmonella enterica serovar Typhimurium (S. Typhimurium) in epithelial cells and macrophages...

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Source

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Identifiers

PMID: 29441327
DOI: 10.3389/fcimb.2018.00008
PMCID: PMC5797601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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