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Article

Specific host genes required for the killing of Klebsiella bacteria by phagocytes.

Cellular microbiology - 1 Jan 2006

Benghezal Mohammed, Fauvarque Marie-Odile, Tournebize Régis, Froquet Romain, Marchetti Anna, Bergeret Evelyne, Lardy Bernard, Klein Gérard, Sansonetti Philippe, Charette Steve J, Cosson Pierre

Abstract excerpt

The amoeba Dictyostelium discoideum shares many traits with mammalian macrophages, in particular the ability to phagocytose and kill bacteria. In response, pathogenic bacteria use conserved mechanisms to fight amoebae and mammalian phagocytes. Here we developed an assay using Dictyostelium to monitor phagocyte-bacteria interactions. Genetic analysis revealed that the virulence of Klebsiella pneumoniae measured by...

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PMID: 16367873
DOI: 10.1111/j.1462-5822.2005.00607.x

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