Protective Role of HLA-DRB1*13:02 against Microscopic Polyangiitis and MPO-ANCA-Positive Vasculitides in a Japanese Population: A Case-Control Study.

doi:10.1371/journal.pone.0154393

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Article

Protective Role of HLA-DRB1*13:02 against Microscopic Polyangiitis and MPO-ANCA-Positive Vasculitides in a Japanese Population: A Case-Control Study.

PloS one - 1 Jan 2016

Kawasaki Aya, Hasebe Narumi, Hidaka Misaki, Hirano Fumio, Sada Ken-Ei, Kobayashi Shigeto, Yamada Hidehiro, Furukawa Hiroshi, Yamagata Kunihiro, Sumida Takayuki, Miyasaka Nobuyuki, Tohma Shigeto, Ozaki Shoichi, Matsuo Seiichi, Hashimoto Hiroshi, Makino Hirofumi, Arimura Yoshihiro, Harigai Masayoshi, Tsuchiya Naoyuki

Abstract excerpt

Among antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), granulomatosis with polyangiitis (GPA) and proteinase 3-ANCA-positive AAV (PR3-AAV) are prevalent in European populations, while microscopic polyangiitis (MPA) and myeloperoxidase-ANCA-positive AAV (MPO-AAV) are predominant in the Japanese. We previously demonstrated association of DRB1*09:01-DQB1*03:03 haplotype, a haplotype common...

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PMID: 27166610
DOI: 10.1371/journal.pone.0154393
PMCID: PMC4868057

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