Article
Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease.
PloS one - 1 Jan 2011
Martins Madalena, Rosa Alexandra, Guedes Leonor C, Fonseca Benedita V, Gotovac Kristina, Violante Sara, Mestre Tiago, Coelho Miguel, Rosa Mário M, Martin Eden R, Vance Jeffery M, Outeiro Tiago F, Wang Liyong, Borovecki Fran, Ferreira Joaquim J, Oliveira Sofia A
Abstract excerpt
miRNAs were recently implicated in the pathogenesis of numerous diseases, including neurological disorders such as Parkinson's disease (PD). miRNAs are abundant in the nervous system, essential for efficient brain function and play important roles in neuronal patterning and cell specification. To further investigate their involvement in the etiology of PD, we conducted miRNA expression profiling in peripheral...
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