Article

iSCORED: nanopore-based random genomic sampling for intraoperative molecular diagnosis

2023-10-18

Abstract excerpt

Copy number variations (CNVs) are almost ubiquitous in cancer. In many cases, somatic CNV analysis has led to the identification of oncogenic pathways and suggested molecular-defined therapeutic targets. Here, we develop iSCORED, a one-step random genomic DNA reconstruction method that enables efficient, unbiased quantification of CNVs using a real-time Nanopore sequencer. By leveraging the long concatenated reads...

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Literature Corpus work: 693e28a6-2e28-5ee1-8139-65ed2bc6ae33
DOI: 10.1101/2023.10.17.23297170

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