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Article

Prognostic impact of germline and somatic variants in lymphoma-associated haemophagocytic lymphohistiocytosis.

British journal of haematology - 1 Sept 2026

Yang Ching-Fen, Yeh Yi-Chen, Hsu Chih-Yi

Abstract excerpt

Lymphoma-associated haemophagocytic lymphohistiocytosis (HLH) is a 'two-hit' disease. Germline heterozygous variants increase susceptibility, while somatic drivers force the crossing of a critical pathogenic threshold.

Read the complete abstract on PubMed

Topics

Humans
Lymphohistiocytosis, Hemophagocytic
Germ-Line Mutation
Prognosis
Lymphoma
Genetic Predisposition to Disease
Genetic Variation

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Source

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Identifiers

PMID: 42413913
DOI: 10.1111/bjh.70674
PMCID: PMC13570148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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