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Article

Somatic mutations in FAS pathway increase hemophagocytic lymphohistiocytosis risk in patients with T- and/or NK-cell lymphoma.

Blood advances - 25 Jun 2024

Liu Ying, Sardana Rohan, Nemirovsky David, Frosina Denise, Jungbluth Achim, Johnson William T, Vardhana Santosha, Arcila Maria, Horwitz Steven M, Derkach Andriy, Dogan Ahmet, Xiao Wenbin

Abstract excerpt

ABSTRACT: Although significant progress has been made in understanding the genetic basis of primary hemophagocytic lymphohistiocytosis (HLH), the pathogenesis of secondary HLH, the more prevalent form, remains unclear. Among the various conditions giving rise to secondary HLH, HLH in patients with lymphoma (HLH-L) accounts for a substantial proportion. In this study, we investigated the role of somatic mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38593227
DOI: 10.1182/bloodadvances.2023011733
PMCID: PMC11222957

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