FCGR2A promoter variant reveals shared genetic susceptibility between IBD and stroke.

doi:10.1007/s11010-026-05631-w

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Article

FCGR2A promoter variant reveals shared genetic susceptibility between IBD and stroke.

Molecular and cellular biochemistry - 1 Aug 2026

Wang Xin, Zhu Zijun, Li Hailong, Gao Jiwei, Ding Mingyang, Li Ying, Shi Lei, Zhu Shimao, Cheng Liang

Abstract excerpt

While the epidemiological association between inflammatory bowel disease (IBD) and stroke is well-established, the shared genetic architecture underlying these diseases remains unclear. This study utilized genome-wide association studies (GWAS) summary statistics to explore genetic overlaps between IBD and stroke subtypes. Mendelian randomization (MR) was applied to assess potential causal relationships....

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Share to Genetic Predisposition to Disease
Share to Genome-Wide Association Study
Share to Inflammatory Bowel Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Receptors, IgG

Share to Stroke

Source

Open in PubMed

Identifiers

PMID: 42400809
DOI: 10.1007/s11010-026-05631-w

Genes

FCGR2A
SPI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.