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Article

Multi-Omics Identifies CTSS as a Susceptibility Gene and Actionable Target That Regulates Melanocyte MHC-II Expression and Survival in Vitiligo.

Pigment cell & melanoma research - 1 Jul 2026

He Ming-Jie, Ren Yi-Jia, Zhang Xiao-Yu, Wang Fang, Xu Hong, Zhu Deng-Jun, Hu Yuan, Zhang Jiang-An

Abstract excerpt

Vitiligo is a common autoimmune disorder characterized by melanocyte loss, yet the molecular mechanisms linking genetic susceptibility to melanocyte dysfunction remain incompletely understood. In this study, we integrated multi-tissue transcriptome-wide association studies (TWAS), summary-data-based Mendelian randomization (SMR), and colocalization analyses to identify causal genes within vitiligo susceptibility...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class II

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Share to STAT1 Transcription Factor

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Source

Identifiers

PMID: 42374868
DOI: 10.1111/pcmr.70107

Genes

CTSS
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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