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Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis

20 Jan 2025

Abstract excerpt

BACKGROUND: Cutaneous melanoma (CM) is strongly associated with ultraviolet (UV) radiation, which contributes to the transformation of melanocytes into melanoma by inducing specific DNA damage. Here, we investigated the causal relationship between CM and genes related to sun-damaged skin, exploring specific target genes through various bioinformatics analyses. METHODS: The Gene Expression Omnibus (GEO) database...

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PMID: 39833734
DOI: 10.1186/s12885-025-13481-w

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